Tramadol is a prescription medication classified as an opioid analgesic, primarily used for the management of moderate to moderately severe pain. It works through a dual mechanism: it binds to opioid receptors in the brain to decrease the perception of pain, while also increasing the levels of neurotransmitters like serotonin and norepinephrine, which can further modulate pain signaling.

As a centrally-acting Schedule IV controlled substance in the United States, its use is regulated due to its potential for misuse, psychological and physical dependence, and addiction. It is approved only for use under strict medical supervision. Common side effects include dizziness, nausea, constipation, headache, and drowsiness, which can impair mental alertness and physical coordination. More serious risks include respiratory depression (especially when combined with other depressants like alcohol or benzodiazepines), seizures, serotonin syndrome (a potentially life-threatening condition from excessive serotonin), and severe withdrawal symptoms upon discontinuation.

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