Individuals who might experience a stronger reaction to Tadalista Professional, which contains tadalafil (a PDE5 inhibitor used for erectile dysfunction), typically include those who are sensitive to its active ingredient or have underlying health conditions. People with cardiovascular issues, such as heart disease or low blood pressure, may experience more pronounced side effects like dizziness or fainting. Elderly patients often have increased sensitivity due to slower metabolism. Additionally, individuals taking nitrate medications or certain alpha-blockers may have intensified reactions because of dangerous blood pressure drops. Those with liver or kidney impairment may also have stronger or prolonged effects due to slower drug clearance. Lastly, people who consume excessive alcohol or have allergies to tadalafil could face heightened adverse reactions.