Fildena CT 50 mg (which contains sildenafil citrate) with grapefruit or grapefruit juice because it can significantly interfere with the way your body processes the medication, leading to increased risk of side effects or toxicity.  Why Grapefruit Juice Is a Problem  1. It Blocks a Key Liver Enzyme (CYP3A4) Sildenafil is broken down in your liver by an enzyme called CYP3A4. Grapefruit juice inhibits this enzyme, meaning more sildenafil stays in your bloodstream longer. 2. This Leads to Higher Blood Levels of Sildenafil This can make the effects stronger and last longer than intended. It also increases the risk of side effects such as: Headache Dizziness or lightheadedness Flushing Low blood pressure Visual disturbances Priapism (prolonged erection)  Is Absorbed Faster Since Fildena CT 50 mg is a chewable formulation, it’s already absorbed more quickly than standard tablets. Combining this with grapefruit juice can further amplify its effects, making the risk even higher.   Bottom Line: Avoid grapefruit juice before and after taking Fildena CT 50 mg—ideally for 24 hours—to prevent unpredictable increases in sildenafil levels and reduce the risk of serious side effects. Would you like a list of foods and drinks that are safe (or risky) to combine with Fildena or similar ED