Fildena 50 contains Sildenafil Citrate, which is commonly used to treat erectile dysfunction (ED). Like other PDE5 inhibitors (such as Viagra or Cialis), Fildena works by increasing blood flow to the penis during sexual arousal. However, drug interactions can occur when Fildena 50 is combined with certain medications, which may either reduce its effectiveness or cause serious side effects. Medications That Can Interact Negatively with Fildena 50 1. Nitrates (Nitroglycerin and Similar Drugs) Common Examples: Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and other nitrate-based medications used for chest pain (angina). Effect of Interaction: Fildena 50 (Sildenafil) can cause a significant drop in blood pressure when taken with nitrates, leading to dizziness, fainting, and even shock. This combination can be life-threatening. Recommendation: If you're taking any form of nitrate medication, avoid Fildena 50 entirely. You should wait at least 24-48 hours after taking Fildena before using nitrate medications (depending on the dose and type of nitrate). 2. Alpha-Blockers Common Examples: Doxazosin, Tamsulosin (Flomax), Alfuzosin, Terazosin, used for high blood pressure or benign prostatic hyperplasia (BPH). Effect of Interaction: Both alpha-blockers and Fildena 50 lower blood pressure. When taken together, they can cause a severe drop in blood pressure, resulting in dizziness, fainting, and a possible risk of heart attack or stroke. Recommendation: If you’re on an alpha-blocker, the dose of either the alpha-blocker or Fildena 50 may need to be adjusted. A doctor should supervise this combination carefully.