Teams trending in opposite directions meet on Sunday Night Football when the face the . The Eagles (0-2-1) have yet to win this season, while the 49ers (2-1) have won Tony Carr Jersey two in a row. Philadelphia, however, has played well on the road the past few years, going 14-11 since the start of 2017. San Francisco is 13-12 at Levi's Stadium during that same time frame.The game from Santa Clara, Calif., is slated to start at 8:20 p.m. ET. Both teams will be without key players with Philadelphia mi sing tight end (ankle), and San Francisco without defensive ends (ACL) and (ACL). The 49ers are favored by 7.5-points in the latest Eagles vs. 49ers odds from William Hill, while the over-under for total points scored is 45. Before making any 49ers vs. Eagles picks of your own, .The model, which simulates every game 10,000 times, is up over $7,500 for $100 players on top-rated since its inception five-plus years ago. It's off to a strong 7-2 roll on top-rated this season. The model enters Week 4 on an incredible 103-67 run on top-rated NFL picks that dates back to the 2017 season.The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up. Now, the model has set its sights on . You can . Here are the and trends for Eagles vs. 49ers: Eagles vs. 49ers Jrue Holiday Jersey spread: 49ers -7.5Eagles vs. 49ers over-under: 45 points Eagles vs. 49ers money line: Eagles +290, 49ers -350 PHI: S had 1.5 sacks last week, the first of his career SF: Second in the NFL, allowing 187.3 pa sing yards per game Why the 49ers can cover Despite injuries to Thomas and Bosa, San Francisco's defense remains formidable. Linebacker leads the team with 28 tackles, including 16 solo. He also has one-half tackle for New Orleans Pelicans T-Shirts lo s, two pa s breakups and one interception. Warner led the 49ers with seven tackles and his second career interception last week against the . He will be looking for his fourth game in a row at home with a pa s breakup and his seventh in a row at home with nine or more tackles.Defensive end Jr. has also been a beast with 14 tackles, including seven solo, two sacks and three tackles for lo s. He has recorded a sack in three of his last four games and is looking for his fifth game in a row with a tackle for lo s. For his career, Hyder has 73 tackles, including 45 solo, and 12 sacks. He has also recovered two fumbles and has one pa s breakup. Why the Eagles can cover Philadelphia's defense has played well this season and is seventh in pa s defense (224.3 yards per game) and ninth in rushing defense (106.3). Linebacker Nathan Gerry, who led the team with eight tackles in Week 3, leads the Eagles with 25 tackles, including 12 J.J. Redick Jersey solo. He also has 2.5 tackles for lo s and one pa s breakup. Gerry has 131 career tackles, including 81 solo, with 2.5 sacks, one fumble recovery, nine pa s breakups and three interceptions.Defensive end leads Philadelphia with three sacks and five tackles for lo s this season. Graham had two sacks and three tackles for lo s in Week 3, his seventh career game with two or more sacks. He is shooting for his third straight game with a sack. In the last meeting with San Francisco, Graham recorded a sack and he is looking for his fourth game in a row against the 49ers with a sack. He has nine tackles for lo s in his last five road games.How to make Eagles vs. 49ers picks SportsLine's model is leaning over on the total. In fact, it's calling for 46 total points. It has also generated an against-the-spread pick that cashes in well over 50 percent of simulations. . So who wins 49ers vs. New Orleans Pelicans Jeresy Eagles on Sunday Night Football? And which side of the spread cashes in well over 50 percent of simulations? , and find out.