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4,4'-Dimethoxytrityl chloride—also known as dimethoxytrityl chloride or dimethoxy trityl chloride—is a vital organic compound widely used in the synthesis of oligonucleotides and other DNA/RNA-related applications. With its distinct protective capabilities, DMT-Cl plays a crucial role in modern molecular biology and pharmaceutical industries.
4,4'-Dimethoxytrityl chloride (CAS Number: 40615-36-9) is an organic chemical compound featuring a trityl (triphenylmethyl) core substituted with two methoxy groups in the 4-positions of the phenyl rings. Its chemical formula is C22H21ClO2.
This compound appears as a white to off-white powder and is commonly abbreviated as DMT-Cl. It is highly reactive due to the presence of a chloride functional group, which allows it to easily form ethers when reacting with alcohols. This reactivity makes it a perfect protecting agent for hydroxyl groups during nucleic acid synthesis.
1. Oligonucleotide Synthesis : The most significant application of DMT-Cl is in the solid-phase synthesis of oligonucleotides, such as DNA and RNA chains. DMT-Cl is used to protect the 5’-hydroxyl group of nucleosides during chain elongation. Once a nucleotide is added, the DMT group can be selectively removed with a mild acid, allowing the next nucleotide to bind.This reversible protection is vital for the accurate assembly of custom DNA sequences, making DMT-Cl a cornerstone reagent in genetic research, diagnostics, and therapeutic development.
2. Peptide and Protein Chemistry : In addition to DNA synthesis, DMT-Cl is also used in peptide synthesis as a protecting group for hydroxyl-containing amino acids like serine and threonine. Its selective reactivity ensures the correct sequence and structure during multi-step synthesis procedures.
3. Pharmaceutical Intermediates : DMT-Cl is used in pharmaceutical research and development as a key intermediate. Its ability to create protected forms of various molecules aids in the design of prodrugs and other bioactive compounds.
When working with dimethoxytrityl chloride, it is essential to follow proper safety procedures:
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4,4'-Dimethoxytrityl chloride (DMT-Cl) is a powerful chemical reagent that plays a fundamental role in the synthesis of nucleotides and peptides. Whether you're conducting cutting-edge genetic research or developing the next breakthrough drug, DMT-Cl is an indispensable part of your toolkit. With high demand in laboratories worldwide, it’s essential to choose a trusted supplier like PharmaNanoAI for the highest quality and reliability.
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